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cyclosporine will improve the degree or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.levoketoconazole will enhance the amount or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.Acute respiratory distress syndrome (ARDS) and acute dif